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KMID : 1134819990280030685
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 3 p.685 ~ p.690
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Effects of Carassius carassius Hot - Water Extracts on Serum Insulin - like Growth Factor - I(IGF - I) and IGF - Binding Proteins in Rats.
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Kwon Mi-Jin
Ryu Hong-Soo
Kim Kyung-Sook
Pyeun Jae-Hyeung
Nam Tak-Jeong
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Abstract
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The insulin-like growth factors(IGFs) are bound to several binding proteins(IGFBPs) that appear
to regulate IGF transfort, receptor binding, and its action. The concentrations of these peptides are regulated by quantity and nutritional quality of dietary proteins. The aim of this study was to compare the effects of two diets, which differed in their protein source, Carassius carassius(CC), Carassius carassius hot-water extract(CCHE), for 4 weeks. Body weight was significantly increased in the CC group(74.14±12.00 to 266.31±36.62g; p＜0.01). Likewise, IGF-I concentration of CC group(101.76±15.90 ng/ml) was significantly higher than that of CCHE group(38.50±11.20ng/ml; p＜0.05). By western immunoblot analysis, especially IGFBP-1, -2 levels are increased, whereas IGFBP-3 level was de-creased in CCHE group. After extraction of browning material from each samples, the extractive was filtered and absorbance at 420㎚ was measured. The absorbance of CCHE group was significantly higher than that of CC group. These results suggest that IGF-I can be employed as an index of protein metabolism, particulary as a simple index in the assessing the status of protein nutrition.
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KEYWORD
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insulin-like growth factors(IGFs), IGF binding proteins, protein nutrition
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